OxIGenoCOM

Partenaire : Pr. Sébastien Hulo

Financeur : Anses

Résumé :

Exposure to aerosols from metalworking fluids (MWF) has previously been related to a series of adverse health outcomes (eg, cancer, respiratory diseases). Our present epidemiological study focuses on occupational exposures to MWF and a panel of exposure and effect biomarkers. We hypothesize that these health outcomes are caused by particle exposure that generates oxidative stress, leading to airway inflammation and ultimately to chronic respiratory diseases. We aimed to assess whether MWF exposure, in particular as characterized by its oxidative potential, is associated with biomarkers of oxidative stress and inflammation as well as genotoxic effects.

The ultimate goal is to develop exposure reduction strategies based on exposure determinants that best predict MWF-related health outcomes. The following relationships will be explored:

1. Exposure determinants and measured exposure
2. Occupational exposure and preclinical and clinical effect markers
3. Exposure biomarkers and biomarkers of effect in both exhaled breath condensate and urine
4. Biomarkers of effect, genotoxic effects and respiratory symptoms.